Flubendazole elicits anti-cancer effects via targeting EVA1A-modulated autophagy and apoptosis in Triple-negative Breast Cancer
Yongqi Zhen, Rongyan Zhao, Minjuan Wang, Xing Jiang, Feng Gao, Leilei Fu, Lan Zhang, Xian‐Li Zhou
Abstract
Our results provide novel insights towards the putative anti-cancer efficacy of flubendazole. Furthermore, here we show that flubendazole could serve as a potential therapeutic drug in TNBC. Altogether, this study highlights the possibility of this repurposed autophagic inducer for future cancer treatments.
Topics & Concepts
Triple-negative breast cancerAutophagyApoptosisBreast cancerCancerCancer researchMedicineOncologyBiologyInternal medicineBiochemistryUbiquitin and proteasome pathwaysAutophagy in Disease and TherapyEpigenetics and DNA Methylation