Mechanisms of Oxidative Stress and Therapeutic Targets following Intracerebral Hemorrhage
Zhenjia Yao, Qinqin Bai, Gaiqing Wang
Abstract
Oxidative stress (OS) is induced by the accumulation of reactive oxygen species (ROS) following intracerebral hemorrhage (ICH) and plays an important role in secondary brain injury caused by the inflammatory response, apoptosis, autophagy, and blood-brain barrier (BBB) disruption. This review summarizes the current state of knowledge regarding the pathogenic mechanisms of brain injury after ICH, markers for detecting OS, and therapeutic strategies that target OS to mitigate brain injury.
Topics & Concepts
Oxidative stressIntracerebral hemorrhageOxidative phosphorylationPharmacologyChemistryNeuroscienceMedicineBiologyBiochemistryInternal medicineSubarachnoid hemorrhageIntracerebral and Subarachnoid Hemorrhage ResearchHydrogen's biological and therapeutic effectsNeurological Disease Mechanisms and Treatments