Is Hysterosalpingo‐Contrast Sonography (<scp>HyCoSy</scp>) Using Sulfur Hexafluoride Microbubbles (<scp>SonoVue</scp>) Sufficient for the Assessment of Fallopian Tube Patency? A Systematic Review and Meta‐Analysis
Enze Qu, Man Zhang, Jinxiu Ju, Ying Chen, Xin Lin, Xinling Zhang
Abstract
This study aimed to evaluate the diagnostic value of HyCoSy using sulfur hexafluoride microbubbles for fallopian tubal patency assessment in infertile females. Twenty-four studies, including 1358 females with 2661 detected fallopian tubes published from January 2003 to May 2019, were identified. The pooled sensitivity was 93% (95% CI: 90-95%), while the specificity was 90% (95% CI: 87-92%). The area under the receiver-operating characteristic curve was 0.96 (95% CI: 94-98%). The specificity of the four-dimensional HyCoSy subgroup was higher than the 2D/3D subgroup; an increased dose of contrast agent did not affect the specificity, with only a slightly reduced sensitivity.
Topics & Concepts
MedicineMicrobubblesFallopian tubeSubgroup analysisSulfur hexafluorideReceiver operating characteristicContrast (vision)Diagnostic accuracyNuclear medicineMeta-analysisGynecologyUltrasoundInternal medicineRadiologyQuantum mechanicsComputer sciencePhysicsArtificial intelligenceGynecological conditions and treatmentsOvarian cancer diagnosis and treatmentOvarian function and disorders