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Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia

Alexander C. Lewis, Emily Gruber, Rheana Franich, Jessica M. Armstrong, Madison J. Kelly, Carlos Opazo, Yau Chung Low, Léa Flippe, Kevin Wijanarko, Caitlin L. Rowe, Celeste Mawal, Alexandra Birrell, Joan So, Srimayee Vaidyanathan, Keziah Ting, Liana N. Semcesen, Karena Last, Ching‐Seng Ang, Giovanna Pomilio, Fiona C. Brown, Andrew H. Wei, Jason A. Powell, Elizabeth S. Ng, Ann E. Frazier, Kate McArthur, Najoua Lalaoui, David A. Stroud, Kristin Brown, Ricky W. Johnstone, Lev M. Kats

2025Cell15 citationsDOI

Topics & Concepts

HemeBiologyMyeloid leukemiaBiosynthesisEnzymeCell biologyBiochemistryCell cultureLeukemiaK562 cellsMetaboliteMyeloidHEK 293 cellsSignal transductionDownregulation and upregulationCytochrome P450MutationCancer researchGeneFunction (biology)CellStem cellProgrammed cell deathGene expressionHeme oxygenaseMitochondrionCytotoxicityRegulation of gene expressionPoint mutationPorphyrin Metabolism and DisordersAcute Myeloid Leukemia ResearchCancer, Hypoxia, and Metabolism
Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia | Litcius