Stereoselective Preparation of <i>C</i>‐Aryl Glycosides <i>via</i> Visible‐Light‐Induced Nickel‐Catalyzed Reductive Cross‐Coupling of Glycosyl Chlorides and Aryl Bromides
Ze‐Dong Mou, Jiaxi Wang, Xia Zhang, Dawen Niu
Abstract
Abstract A nickel‐catalyzed cross‐coupling reaction of glycosyl chlorides with aryl bromides has been developed. The reaction proceeds smoothly under visible‐light irradiation and features the use of bench‐stable glycosyl chlorides, allowing the highly stereoselective synthesis of C ‐aryl glycosides. magnified image
Topics & Concepts
ChemistryGlycosylArylStereoselectivityNickelCatalysisCoupling reactionGlycosideCombinatorial chemistryOrganic chemistryMedicinal chemistryAlkylRadical Photochemical ReactionsCarbohydrate Chemistry and SynthesisSulfur-Based Synthesis Techniques