Brønsted acid-catalyzed regioselective ring opening of 2 <i>H</i> -azirines by 2-mercaptopyridines and related heterocycles; one pot access to imidazo[1,2- <i>a</i> ]pyridines and imidazo[2,1- <i>b</i> ]thiazoles
Subrata Biswas, Subrata Biswas, Arnab Roy, Surajit Duari, Srabani Maity, Asma M. Elsharif, Srijit Biswas, Srijit Biswas
Abstract
-azirines, 2-mercaptopyridines, and thiazole-2-thiols, illustrating the generality of reaction conditions. The practical applications include the synthesis of pharmaceuticals, such as anti-tumor agents. This study introduces a novel approach to the synthesis of functional molecules with extensive potential.
Topics & Concepts
RegioselectivityCatalysisRing (chemistry)ChemistryCombinatorial chemistryBrønsted–Lowry acid–base theoryMedicinal chemistryStereochemistryOrganic chemistrySynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsClick Chemistry and Applications