New 1,3,4-thiadiazoles as potential anticancer agents: pro-apoptotic, cell cycle arrest, molecular modelling, and ADMET profile
Mohamed H. Hekal, Paula S. Farag, Magdy M. Hemdan, Amira A. El‐Sayed, Aya I. Hassaballah, Wael M. El‐Sayed
Abstract
studies showed that these derivatives have a low blood-brain barrier penetration capability and high intestinal absorption. Taken together, derivatives 6b and 19 could serve as potential anticancer agents and merit further investigations.
Topics & Concepts
Cyclin-dependent kinase 1ApoptosisCell cycle checkpointLipinski's rule of fiveChemistryPharmacologyPenetration (warfare)Cell cycleStereochemistryBiochemistryBiologyEngineeringIn silicoOperations researchGeneSynthesis and biological activitySynthesis and Characterization of Heterocyclic CompoundsClick Chemistry and Applications