High expression of TREM2 promotes EMT via the PI3K/AKT pathway in gastric cancer: bioinformatics analysis and experimental verification
Chunmei Li, Xiaoming Hou, Shuqiao Yuan, Yigan Zhang, Wenzhen Yuan, Xiaoguang Liu, Juan Li, Yuping Wang, Quanlin Guan, Yongning Zhou
Abstract
Background: To date, the pathogenesis of gastric cancer (GC) remains unclear. We combined public database resources and bioinformatics analysis methods, explored some novel genes and verified the experiments to further understand the pathogenesis of GC and to provide a promising target for anti-tumor therapy.
Topics & Concepts
TREM2PI3K/AKT/mTOR pathwayCancerCancer researchMedicineBioinformaticsProtein kinase BComputational biologyBiologyInternal medicineSignal transductionCell biologyMyeloidMyeloid cellsInflammation biomarkers and pathwaysImmune cells in cancerPharmacological Effects of Natural Compounds