Integrin β3 promotes cardiomyocyte proliferation and attenuates hypoxia-induced apoptosis via regulating the PTEN/Akt/mTOR and ERK1/2 pathways
Lijiang Wei, Qingqing Zhou, Hua Tian, Yifan Su, Guo‐Hui Fu, Ting Sun
Abstract
Objective: Integrin 3 is one of the main integrin heterodimer receptors on the surface of cardiac myocytes. Our previous studies showed that hypoxia induces apoptosis and increases integrin 3 expression in cardiomyocytes. However, the exact mechanism by which integrin 3 protects against apoptosis remains unclear. Hence, the present investigation aimed to explore the mechanism of integrin 3 in cardiomyocyte proliferation and hypoxia-induced cardiomyocyte apoptosis.
Topics & Concepts
IntegrinPI3K/AKT/mTOR pathwayCollagen receptorCell biologyProtein kinase BApoptosisSignal transductionIntegrin alpha MChemistryBiologyCancer researchMolecular biologyCellFlow cytometryBiochemistryCell Adhesion Molecules ResearchCancer, Hypoxia, and Metabolisminterferon and immune responses