Recent Applications and Trends in the Julia‐Kocienski Olefination
Pulluparambil Xavier Thresia Rinu, Sankaran Radhika, Gopinathan Anilkumar
Abstract
Abstract The Julia‐Kocienski (J‐K) olefination is a modified version of Julia‐Lythgoe olefination. In this reaction, an aldehyde or ketone is coupled with heterocycle‐bearing sulfone in the presence of a strong base to yield alkene. It has shown wide application in the synthesis of olefinic fragments in natural product synthesis. The Julia‐ Kocienski olefination is one of the most efficient protocols for the synthesis of E‐ alkenes. Nowadays, a variety of natural products were synthesised by using the Julia‐Kocienski olefination as the key step, and several developments and modifications were witnessed in this area. This review comprehends the recent developments and achievements in Julia‐Kocienski olefination along with its application in natural product synthesis covering literature from 2016 to 2021.