Structurally diverse G-quadruplexes as the noncanonical nucleic acid drug target for live cell imaging and antibacterial study
Bo‐Xin Zheng, Jie Yu, Wei Long, Ka Hin Chan, Alan Siu‐Lun Leung, Wing‐Leung Wong
Abstract
, and the mRNA G4-sites in the sequence for coding the vital bacterial FtsZ protein are highlighted to further explore in G4-drug development against human diseases.
Topics & Concepts
Nucleic acidG-quadruplexChemistryDrugCellCombinatorial chemistryLive cell imagingDNANanotechnologyBiochemistryBiologyPharmacologyMaterials scienceDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene Delivery