Mechanochemical synthesis of aromatic sulfonamides
Satenik Mkrtchyan, Viktor O. Iaroshenko
Abstract
and amine with aryl bromides or aromatic carboxylic acids was developed. This strategy was developed to utilise mechanical energy and accommodate primary as well as secondary aliphatic and aromatic amines to provide a new shortcut to a wide range of sulfonamides. Studies on the scope and limitations of the reaction indicated its tolerance of a vast range of functional groups and many structural patterns. The reactions were scaled up to gram quantities.
Topics & Concepts
Primary (astronomy)ChemistryArylAromatic amineAmine gas treatingScope (computer science)Combinatorial chemistryOrganic chemistryReaction conditionsFunctional groupCatalysisComputer scienceAstronomyAlkylPolymerPhysicsProgramming languageSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods