Peptides as Pharmacological Carriers to the Brain: Promises, Shortcomings and Challenges
Sofia Parrasia, Ildikò Szabó, Mario Zoratti, Lucia Biasutto
Abstract
, caused by the presence of peptidases, the vulnerability to endosomal/lysosomal degradation, and the frequently still insufficient attainable increase of brain drug levels, which remain below the therapeutically useful concentrations. The aim of this review is to analyze not only the successful and promising aspects of the use of peptides in brain targeting but also the problems posed by this strategy for drug delivery.
Topics & Concepts
TranscytosisBlood–brain barrierPeptideEndosomeNeuroscienceIn vivoEndocytosisReceptorPharmacologyComputational biologyChemistryBiologyMedicineCentral nervous systemBiochemistryBiotechnologyRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesNanoparticle-Based Drug Delivery