<i>In vitro</i> to <i>in vivo</i> extrapolation to support the development of the next generation risk assessment (NGRA) strategy for nanomaterials
Karolina Jagiełło, Krzesimir Ciura
Abstract
-relevant responses are presented. We also discuss the limitations of models applied thus far to study the fate of chemicals in the human body, which exist due to the lack of available knowledge regarding transformations of nanomaterials occurring in biological systems.
Topics & Concepts
ExtrapolationIn vivoPhysiologically based pharmacokinetic modellingRisk assessmentIn vitroDevelopment (topology)Computer scienceRisk analysis (engineering)Biochemical engineeringNanotechnologyChemistryPharmacologyMedicineBiologyMaterials scienceEngineeringPharmacokineticsBiotechnologyMathematicsStatisticsComputer securityMathematical analysisBiochemistryNanoparticles: synthesis and applicationsChemistry and Chemical Engineering