Armed with IL-2 based fusion protein improves CAR-T cell fitness and efficacy against solid tumors

Sijin Li, Yi-Fei Xia, Rui Hou, Xu Wang, Xuan Zhao, Zhangchun Guan, Wen Ma, Yutong Xu, Wei Zhang, Dan Liu, Junnian Zheng, Ming Shi

2024Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease14 citationsDOI

Topics & Concepts

Chimeric antigen receptorImmunotherapyImmune systemCancer researchT cellAntigenInterleukin 2Fusion proteinTumor microenvironmentMedicineImmunologyBiologyRecombinant DNABiochemistryGeneCAR-T cell therapy researchVirus-based gene therapy researchNanowire Synthesis and Applications