Synthesis of novel polymeric nanoparticles (methoxy-polyethylene glycol-chitosan/hyaluronic acid) containing 7-ethyl-10-hydroxycamptothecin for colon cancer therapy: <i>in vitro, ex vivo</i> and <i>in vivo</i> investigation
Faezeh Sharifi, Mansour Jahangiri, Pedram Ebrahimnejad
Abstract
study indicated that SN38-NPs were more potent against the cancer cells than free SN38. The cellular uptake of SN38-NPs improved up to 1.6-fold against human colorectal adenocarcinoma (Caco-2) cells. Moreover, SN38-NPs remarkably demonstrated superior anti-tumor efficacy in contrary to pure SN38. This suggests the advantage of SN38-NPs as a potent oral drug carrier which could be further explored for clinical investigations.
Topics & Concepts
ChitosanPolyethylene glycolIn vivoEx vivoMaterials scienceHyaluronic acidNanoparticlePEG ratioDifferential scanning calorimetryNuclear chemistryIn vitroChemistryNanotechnologyOrganic chemistryBiochemistryMedicinePhysicsBiologyBiotechnologyFinanceThermodynamicsAnatomyEconomicsNanoparticle-Based Drug DeliveryDrug Transport and Resistance MechanismsIntraperitoneal and Appendiceal Malignancies