Constipation is associated with an increased risk of major adverse cardiac events in a UK population
Tenghao Zheng, Letícia Camargo Tavares, Mauro D’Amato, Francine Z. Marques
Abstract
Analyzing 408,354 participants of the UK Biobank, we show that constipation cases exhibited a significantly higher risk of major adverse cardiac events (MACEs) than those with regular bowel habits. In comparison with patients with constipation-free hypertension, patients with hypertension with constipation showed significantly higher odds of MACE and a 34% increased risk of subsequent MACE occurrence. Finally, we detected positive genetic correlations between constipation and MACE. This association holds potential for therapeutic exploitation and prevention based on individuals' risk assessment.
Topics & Concepts
ConstipationMedicineAdverse effectPopulationIntensive care medicineInternal medicineEnvironmental healthGastrointestinal motility and disordersHelicobacter pylori-related gastroenterology studiesDiet and metabolism studies