Novel adamantane-pyrazole and hydrazone hybridized: Design, synthesis, cytotoxic evaluation, SAR study and molecular docking simulation as carbonic anhydrase inhibitors
Mohammed M. S. Wassel, Ahmed Ragab, Gameel A. M. El‐Hag Ali, Ahmed B. M. Mehany, Yousry A. Ammar
Topics & Concepts
ChemistryAdamantanePyrazoleHydrazoneDocking (animal)Carbonic anhydraseStereochemistryIC50Active siteCarbonic anhydrase IICombinatorial chemistryEnzymeIn vitroBiochemistryOrganic chemistryNursingMedicineEnzyme function and inhibitionSynthesis and biological activitySynthesis and Biological Evaluation