In vivo evaluation of combination therapy targeting the isoprenoid biosynthetic pathway
Staci L. Haney, Michelle L. Varney, Yashpal S. Chhonker, Geoffrey A. Talmon, Lynette M. Smith, Daryl J. Murry, Sarah A. Holstein
Topics & Concepts
GeranylgeranylationGeranylgeranyl pyrophosphateMevalonate pathwayIn vivoPharmacologyLovastatinStatinCombination therapyFarnesyl pyrophosphateMedicinePrenylationBiologyBiochemistryInternal medicineEnzymeCholesterolATP synthaseBiotechnologyReductaseCancer, Lipids, and MetabolismCancer, Hypoxia, and MetabolismUbiquitin and proteasome pathways