Tet1 deficiency exacerbates oxidative stress in acute kidney injury by regulating superoxide dismutase
Fan Yu, Yangmian Yuan, Mingrui Xiong, Muchuan Jin, Donge Zhang, Dong Yang, Chengyu Liu, Robert B. Petersen, Kun Huang, Anlin Peng, Ling Zheng
Abstract
Tet1 plays an important role in the development of AKI by promoting SOD expression through a DNA demethylase-dependent mechanism.
Topics & Concepts
SOD2Reactive oxygen speciesOxidative stressAcute kidney injurySuperoxide dismutaseCancer researchChemistryKidneyMolecular biologyBiologyMedicineCell biologyInternal medicineEndocrinologyBiochemistryAcute Kidney Injury ResearchDialysis and Renal Disease ManagementCardiac Arrest and Resuscitation