Liposomal cyanine dyes with enhanced nonradiative transition for the synergistic phototherapy of tumors
Yuan Wang, Di Liu, Meng You, Hong Yang, Hengte Ke
Abstract
enhanced nonradiative transition through π-π aggregation. Lipo-Cy further enhanced the cellular uptake of Cypate, as well as preferable tumor accumulation and retention, leading to abundant intracellular singlet oxygen and potent hyperthermia at the tumor for effective PTT synergized PDT, even at dosages 10 times less than free Cypate. The Lipo-Cy exhibited superior anticancer efficiency, showing great prospects for clinical translation.
Topics & Concepts
CyanineLiposomePhotochemistryMaterials scienceBiophysicsTransition (genetics)ChemistryNanotechnologyFluorescenceOpticsBiochemistryPhysicsBiologyGeneNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesNanoparticle-Based Drug Delivery