TRIM21 inhibits the osteogenic differentiation of mesenchymal stem cells by facilitating K48 ubiquitination-mediated degradation of Akt
Jiaqi Xian, Daochen Liang, Chengyi Zhao, Yaowu Chen, Qingàn Zhu
Topics & Concepts
Mesenchymal stem cellUbiquitin ligaseUbiquitinCell biologyProtein kinase BBiologyDownregulation and upregulationSignal transductionBiochemistryGeneinterferon and immune responsesChemokine receptors and signalingUbiquitin and proteasome pathways