IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis
Jinqiang Zhang, Peijing Rong, Lijuan Zhang, Hui He, Tao Zhou, Yonghua Fan, Li Mo, Qiuying Zhao, Yue Han, Shaoyuan Li, Yifei Wang, Yan Wan, Huafu Chen, Zili You
Abstract
microglia in the hippocampus by enhancing IL4 signaling restored hippocampal neurogenesis and the resilience to stress-induced depression. Brain-derived neurotrophic factor (BDNF) was found necessary for the proneurogenesis effects of IL4-driven microglia. Together, our findings suggest that IL4-driven microglia in the hippocampus trigger BDNF-dependent neurogenesis responding to chronic stress, helping protect against depressive-like symptoms. These findings identify the modulation of a specific microglial phenotype as a treatment strategy for mood disorders.
Topics & Concepts
NeurogenesisMicrogliaResilience (materials science)NeuroscienceInterleukin 4InflammationBiologyPsychologyImmunologyCytokinePhysicsThermodynamicsNeuroinflammation and Neurodegeneration MechanismsTryptophan and brain disordersNeurogenesis and neuroplasticity mechanisms