In vitro and in vivo antiviral activity of monolaurin against Seneca Valley virus
Bo Su, Yingjie Wang, Shanqiu Jian, Huaqiao Tang, Huidan Deng, Ling Zhu, Xiaonan Zhao, Jian Liu, Huangzuo Cheng, Lina Zhang, Youjun Hu, Zhiwen Xu
Abstract
Introduction: (SVV) shows a disproportionately higher incidence on Chinese pig farms. Currently, there are no vaccines or drugs to treat SVV infection effectively and effective treatment options are urgently needed. Methods: In this study, we evaluated the antiviral activity of the following medium-chain fatty acids (MCFAs) or triglycerides (MCTs) against SVV: caprylic acid, caprylic monoglyceride, capric monoglyceride, and monolaurin. Results: studies showed that monolaurin reduced clinical manifestations, viral load, and organ damage in SVV-infected piglets. Monolaurin significantly reduced the release of inflammatory cytokines and promoted the release of interferon-γ, which enhanced the viral clearance activity of this type of MCFA. Discussion: Therefore, monolaurin is a potentially effective candidate for the treatment of SVV infection in pigs.