An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity
Seth Carbonneau, Sujata Sharma, Liaomin Peng, Vaisakh Rajan, Dominik Hainzl, Martin Hénault, Chian Yang, Jacob A. Hale, Janine Shulok, John A. Tallarico, Jeff Porter, Jennifer L. Brogdon, Glenn Dranoff, James E. Bradner, Marc Hild, Carla Guimarães
Topics & Concepts
DegronCell biologyChimeric antigen receptorChemistryBiologyImmunologyBiochemistryImmune systemGeneImmunotherapyUbiquitinUbiquitin ligaseCAR-T cell therapy researchProtein Degradation and InhibitorsImmunotherapy and Immune Responses