Inhalation of acidic nanoparticles prevents doxorubicin cardiotoxicity through improvement of lysosomal function
Yohan Santin, Karina Formoso, Fraha Haidar, Maria Del Pilar Oreja Fuentes, Florence Bourgailh, Nesrine Hifdi, Karim Hnia, Yosra Doghri, Jessica Resta, Camille Champigny, Séverine Lechevallier, Maximin Détrait, Grégoire Cousin, Malik Bisserier, Angelo Parini, Frank Lezoualc’h, Marc Verelst, Jeanne Mialet‐Perez
Abstract
Our findings demonstrate a pivotal role for lysosomal dysfunction in Dox-induced cardiomyopathy and highlight for the first time that pulmonary-driven NPs-PLGA administration is a promising strategy against anthracycline cardiotoxicity.
Topics & Concepts
CardiotoxicityPLGADoxorubicinPharmacologyAutophagyCardiomyopathyAnthracyclineBafilomycinChemistryCardiac function curveIn vivoMedicineHeart failureToxicityIn vitroChemotherapyBiochemistryCancerInternal medicineApoptosisBiologyBreast cancerBiotechnologyCalcium signaling and nucleotide metabolismChemotherapy-induced cardiotoxicity and mitigationElectron Spin Resonance Studies