Extended-Spectrum β-Lactamase Genes Traverse the Escherichia coli Populations of Intensive Care Unit Patients, Staff, and Environment
Robert A. Moran, Baomo Liu, Emma L. Doughty, Yingyi Guo, Xiaoliang Ba, Willem van Schaik, Chao Zhuo, Alan McNally
Abstract
ESBL resistance significantly impacts clinical management of E. coli infections in hospitals globally. It is important to understand the structures of ESBL-EC populations carried by hospital patients and staff, their capacity to persist in hospital environments, and the dynamics of mobile genes that drive the spread of ESBL resistance.
Topics & Concepts
PlasmidBiologyPopulationInsertion sequenceEscherichia coliGeneticsGeneIntensive care unitPiperacillinChromosomeGenomeMedicinePseudomonas aeruginosaTransposable elementBacteriaEnvironmental healthInternal medicineAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyPharmaceutical and Antibiotic Environmental Impacts