Metformin enhances the sensitivity of colorectal cancer cells to cisplatin through ROS-mediated PI3K/Akt signaling pathway
Pei Zhang, Surong Zhao, Xingyue Lu, Zongfen Shi, Hao Liu, Bing Zhu
Topics & Concepts
PI3K/AKT/mTOR pathwayCisplatinMetforminProtein kinase BViability assayApoptosisReactive oxygen speciesBiologySignal transductionCancer researchDownregulation and upregulationCell biologyPharmacologyEndocrinologyBiochemistryChemotherapyDiabetes mellitusGeneticsGenePI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and CancerChemotherapy-induced organ toxicity mitigation