Pharmacodynamic monitoring of factor VIII replacement therapy in hemophilia A: Combining thrombin and plasmin generation
L. L. F. G. Valke, Laura H. Bukkems, Wideke Barteling, Britta A. P. Laros‐van Gorkom, Nicole M. A. Blijlevens, Ron A. A. Mathôt, Waander L. van Heerde, Saskia E.M. Schols
Topics & Concepts
PharmacokineticsPharmacodynamicsMedicineThrombin generationInterquartile rangeHemostasisPlasminThrombinInternal medicineArea under the curveGastroenterologyPlateletChemistryBiochemistryEnzymeHemophilia Treatment and ResearchBlood properties and coagulationCoagulation, Bradykinin, Polyphosphates, and Angioedema