S-nitrosothiols loaded mini-sized Au@silica nanorod elicits collagen depletion and mitochondrial damage in solid tumor treatment
Ping Liu, Yidan Wang, Yang Liu, Fengping Tan, Jining Li, Nan Li
Abstract
This work points out a strategy to overcome the obstacle standing in nanoparticles penetration, and opens the door of further exploitation of NO-related theranostic systems.
Topics & Concepts
BiophysicsChemistryExtracellular matrixMatrix metalloproteinasePeroxynitriteTumor microenvironmentPhotothermal therapyNanoparticleSuperoxideMaterials scienceNanotechnologyBiochemistryCancer researchBiologyTumor cellsEnzymeNanoplatforms for cancer theranosticsProtease and Inhibitor MechanismsAngiogenesis and VEGF in Cancer