Efficient discrimination of transplutonium actinides by <i>in vivo</i> models
Roger M. Pallares, Dahlia D. An, Gauthier J.‐P. Deblonde, Birgitta Kullgren, Stacey Gauny, Erin Jarvis, Rebecca J. Abergel
Abstract
Notably, the organ deposition patterns of those transplutonium actinides were element-dependent, particularly in the liver and skeleton, where lower atomic number radionuclides showed up to 7-fold larger liver/skeleton accumulation ratios. Nevertheless, the metal content in multiple organs was significantly decreased for all tested actinides, particularly in the liver, after administering the therapeutic agent 3,4,3-LI(1,2-HOPO) post-contamination. Lastly, the systematic comparison of the radionuclide biodistributions showed discernibly element-dependent organ depositions, which may provide insights into design rules for new bio-inspired chelating systems with high sequestration and separation performance.