Nanoparticles induced neurotoxicity
Divya Bajpai Tripathy, Subhalaxmi Pradhan, Anjali Gupta, Pooja Agarwal
Abstract
The early development of nanotechnology has spurred major interest on the toxicity of nanoparticles (NPs) due to their ability to penetrate the biological barriers such as the BBB. This review aims at addressing how silver (AgNPs), titanium dioxide (TiO2NPs), zinc oxide (ZnONPs), iron oxide (Fe3O4NPs), carbon NPs, Copper (Cu-NPs), silicon oxide (SiO2 NPs) nanoparticles and quantum dots cause neurotoxicity. Some of the major signaling that occur are the signaling related to oxidative stress, neuroinflammation, mitochondrial dysfunction and cell equilibrium, hence results in neuronal damage and neurodegeneration. It is critical to describe that there are multiple ways by how NPs may be toxic based on their size and surface, dosage, and the recipient’s age and health condition. A review on in vitro and in vivo analysis provides information about the toxic potentials of NPs and preventive measures including modification of NP surface and antioxidant treatment. The results underline the necessity of comprehensive safety assessments to allow the further utilization of nanoparticles across the economy.