Discovery of a potent CDKs/FLT3 PROTAC with enhanced differentiation and proliferation inhibition for AML
Mingfei Wu, Wei Wang, Xinfei Mao, Yiquan Wu, Yuyuan Jin, Tao Liu, Yan Lu, Haibin Dai, Shenxin Zeng, Wenhai Huang, Yuwei Wang, Xiaojun Yao, Jinxin Che, Meidan Ying, Xiaowu Dong
Topics & Concepts
ChemistryCyclin-dependent kinase 2Progenitor cellCell growthCyclin-dependent kinaseCellular differentiationCell biologyCancer researchStem cellLinkerCellCell cycleBiochemistryBiologyGeneComputer scienceOperating systemProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsHistone Deacetylase Inhibitors Research