Targeting PRDX6-dependent localization and function of GPX4 enhances ferroptosis-mediated tumor suppression
Yameng Hu, Ziwen Li, Man Li, Xingui Wu, Shuxia Zhang, Miaoling Tang, Ruyuan Yu, Meisongzhu Yang, Xin Chen, Libing Song, Guido Kroemer, Valerian E. Kagan, Hülya Bayir, Rui Kang, Jinbao Liu, Daolin Tang, Jun Li
Topics & Concepts
GPX4BiologyPhospholipid-hydroperoxide glutathione peroxidaseFunction (biology)Cell biologySuppressorPeroxiredoxinCancer researchCancer cellCancerPhospholipase A2Mechanism (biology)GlutathioneBiochemistryPhospholipaseTumor suppressor genePhospholipase ALipid dropletCysteineLipid peroxidationLipid-anchored proteinPhospholipase DCell membraneLipid metabolismInducerDownregulation and upregulationChromosomal translocationGlutathione peroxidaseGeneSubcellular localizationPeroxidaseIntracellularFerroptosis and cancer prognosisRedox biology and oxidative stressSelenium in Biological Systems