Rapid, room-temperature self-organization of polyarylated 1<i>H</i>-pyrroles from acetylenes and nitriles in the KOBu<sup><i>t</i></sup>/DMSO system
Elena Yu. Schmidt, Inna V. Tatarinova, N. A. Lobanova, Igor А. Ushakov, Irina Yu. Bagryanskaya, Б. А. Трофимов
Abstract
A new family of polysubstituted pyrroles became readily accessible in a simple one-step procedure from acetylenes and nitriles under mild (room temperature, 15 min), transition-metal-free conditions.
Topics & Concepts
ChemistryIntramolecular forceNitrileCarbanionArylRing (chemistry)Nucleophilic additionPyrroleMedicinal chemistryYield (engineering)MoleculeTriple bondNucleophilePolymer chemistryStereochemistryOrganic chemistryDouble bondCatalysisMetallurgyAlkylMaterials scienceSynthesis and Characterization of PyrrolesFluorine in Organic ChemistryPorphyrin and Phthalocyanine Chemistry