Electrostatically-directed Pd-catalysis in combination with C–H activation: site-selective coupling of remote chlorides with fluoroarenes and fluoroheteroarenes
William A. Golding, Robert J. Phipps
Abstract
a concerted metalation deprotonation-type mechanism. This results in site-selective cross-coupling of dichloroarenes with fluoroarenes and fluoroheteroarenes, with selectivity controlled by catalyst structure. This study demonstrates that Pd-catalyzed C-H activation can be used productively in combination with a non-covalently-directed mode of catalysis, with important implications in both fields.
Topics & Concepts
CatalysisChemistryOxidative coupling of methaneCoupling (piping)PhotochemistryCombinatorial chemistryOxidative phosphorylationOrganic chemistryMaterials scienceBiochemistryMetallurgyCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis