Model-Oriented Dose Optimization of Voriconazole in Critically Ill Children
Jun Wang, Hua Xu, Ran Li, Sanlan Wu, Jili Zou, Yang Wang
Abstract
. The maintenance dose of VRC was supposed to decrease slightly when coadministered with omeprazole. A population PK model of intravenous VRC for critically ill children has been successfully developed. It is necessary to adjust dosing regimens according to the CYP2C19 genotype. Optimal dosing regimens have been recommended based on the final model.
Topics & Concepts
CminDosingMedicineRegimenMaintenance doseCmaxPharmacokineticsCYP2C19Therapeutic drug monitoringLoading dosePopulationVoriconazoleTrough ConcentrationPharmacologyInternal medicineMetabolismDermatologyAntifungalCytochrome P450Environmental healthAntifungal resistance and susceptibilityAntibiotics Pharmacokinetics and EfficacyPneumocystis jirovecii pneumonia detection and treatment