Cardamonin induces G2/M phase arrest and apoptosis through inhibition of NF-κB and mTOR pathways in ovarian cancer
Jiang Ruibin, Bo Jin, Danying Wan, Feng Jianguo, Linhui Gu
Abstract
. The effects of cardamonin on cell cycle patterns and apoptotic responses of cells were assessed in this study. Western blot was employed to determine the effects of cardamonin on expression of cell cycle- and apoptosis-related proteins. Our results indicate that cardamonin suppresses cancer cell growth by inducing G2/M phase arrest and apoptosis through targeted inhibition of NF-κB and mTOR pathways. The collective findings provide novel insights into the pathways responsible for the anticancer effects of cardamonin and support its potential utility as a clinical therapeutic agent for ovarian cancer.
Topics & Concepts
PI3K/AKT/mTOR pathwayApoptosisNF-κBCancer researchOvarian cancerCell cycle checkpointSignal transductionChemistryCancerMedicineInternal medicineCell cycleBiochemistryGenomics, phytochemicals, and oxidative stressGinger and Zingiberaceae researchFree Radicals and Antioxidants