Synthesis and Biological Activity of Some Novel Derivatives of4-[5-(2,3-Dihydrobenzo[b][1,4]dioxin-7-yl)isoxazole-3-yl]benzoic Acid
Vijai Varma Pothuri, P.V.S. Machiraju, V. Samba Siva Rao
Abstract
Some novel isoxazole derivatives of 4-[5-(2,3-dihydrobenzo[b][1,4]dioxin-7-yl)isoxazole-3-yl]benzoic acid bearing biologically active pharmacophores like benzodioxane and peptide bond have been synthesized, and their structures are supported by FTIR,1H and 13C NMR, and mass spectra. The title compounds have been tested for antimicrobial and antioxidant activities. Molecular docking of the structures has also been carried out with protein Sortase A, according to which some compounds are characterized as potentially antimicrobial agents. Four products demonstrate strong antioxidant activity.
Topics & Concepts
ChemistryIsoxazolePharmacophoreAntimicrobialBenzoic acidStereochemistryCarbon-13 NMRAntioxidantProton NMRBiological activityCombinatorial chemistryOrganic chemistryBiochemistryIn vitroBiochemical and Structural CharacterizationPhytochemistry and Biological ActivitiesChemical synthesis and alkaloids