Mycobiome Dysbiosis in Women with Intrauterine Adhesions
Ningning Liu, Xingping Zhao, Jing-Cong Tan, Sheng Liu, Bowen Li, Wanxing Xu, Peng Lin, Pan Gu, Waixing Li, Rebecca S. Shapiro, Xiaoqi Zheng, Wenjing Zhao, Yiguo Jiang, Dan Chen, Dabao Xu, Hui Wang
Abstract
Intrauterine adhesion (IUA) often leads to hypomenorrhea, amenorrhea, repeat miscarriages, and infertility. It has been prevalent over the last few decades in up to 13% of women who experience pregnancy termination during the first trimester, and 30% of women undergo dilation and curettage after a late, spontaneous abortion. However, the pathogenesis of IUA remains unclear. Despite reports of microbiota dysbiosis during IUA progression, there is little information on the effect of fungal microbiota on the development of IUA. This study not only enhances our understanding of the mycobiome in IUA patients but also provides potential intervention strategies for prevention of IUA by targeting mycobiome.