Protective effect of LNA-anti-miR-132 therapy on liver fibrosis in mice
Fatemeh Momen‐Heravi, Donna Catalano, Austin Talis, Gyöngyi Szabó, Shashi Bala
Abstract
studies suggest miR-132 targets SIRT1 and inflammatory genes. Using tumor cancer genome atlas data, an increase in miR-132 was found in hepatocellular carcinoma (HCC). Increased miR-132 levels were associated with fibrogenic genes, higher tumor grade and stage, and unfavorable survival in HCC patients. Therapeutic inhibition of miR-132 might be a new approach to alleviate liver fibrosis, and treatment efficacy can be monitored by observing EV shedding.
Topics & Concepts
FibrosisHepatocellular carcinomaCirrhosisIn vivoLiver cancermicroRNACancer researchMedicineHepatic stellate cellCCL4BiologyPathologyInternal medicineChemistryGeneCarbon tetrachlorideBiotechnologyBiochemistryOrganic chemistryMicroRNA in disease regulationExtracellular vesicles in diseaseCircular RNAs in diseases