Inhibition of macrophage inflammasome assembly and pyroptosis with GC-1 ameliorates acute lung injury
Bin Li, Jingyi Liu, Wanyu He, Yanlin Zhou, Man Zhao, Cong Xia, Xiaoyue Pan, Zhihua Ji, Ruoyu Duan, Hui Lian, Kai Xu, Guoying Yu, Lan Wang
Abstract
This study presents a novel mechanism for treating ALI in which GC-1 inhibits macrophage ROS-mediated inflammasome assembly and pyroptosis through Nrf2-p53-ASC pathway. These findings highlight the promising potential of the use of GC-1 as an anti-inflammatory and antioxidant drug in the treatment of ALI/ARDS.
Topics & Concepts
PyroptosisInflammasomeMacrophageCaspase 1Alveolar macrophageLungChemistryInflammationMedicineImmunologyBiochemistryIn vitroInternal medicineInflammasome and immune disordersPulmonary Hypertension Research and Treatments