Autosis
Jihoon Nah, Daniela Zablocki, Junichi Sadoshima
Abstract
Excessive autophagy induces a defined form of cell death called autosis, which is characterized by unique morphological features, including ballooning of perinuclear space and biochemical features, including sensitivity to cardiac glycosides. Autosis is observed during the late phase of reperfusion after a period of ischemia and contributes to myocardial injury. This review discusses unique features of autosis, the involvement of autosis in myocardial injury, and the molecular mechanism of autosis. Because autosis promotes myocardial injury under some conditions, a better understanding of autosis may lead to development of novel interventions to protect the heart against myocardial stress.
Topics & Concepts
AutophagyCardiologyMedicineMyocardial ischemiaIschemiaInternal medicineMechanism (biology)Cardiac cellReperfusion injuryBiologyBiochemistryApoptosisPhilosophyEpistemologyAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseaseFuel Cells and Related Materials