Imperatorin Inhibits Proliferation, Migration, and Inflammation <i>via</i> Blocking the NF-κB and MAPK Pathways in Rheumatoid Fibroblast-like Synoviocytes
Wei Lin, Gang Chen, Yuhang Mao, Xuemei Ma, Junnan Zhou, Xiaolu Yu, Chaoliang Wang, Mei Liu
Abstract
the mitogen-activated protein kinase (MAPK) (p38 and ERK) and NF-κB pathways leading to the down-regulation of pro-inflammatory cytokines, which might be beneficial to the anti-proliferative and anti-migratory activities of FLS cells. These findings suggest that IPT has the potential to be developed as a novel agent for RA treatment.
Topics & Concepts
MAPK/ERK pathwayp38 mitogen-activated protein kinasesInflammationTumor necrosis factor alphaSignal transductionNF-κBProinflammatory cytokineCell biologyIκBαKinaseCancer researchFibroblastChemistryImmunologyPharmacologyMedicineBiologyBiochemistryIn vitroNF-κB Signaling PathwaysNatural product bioactivities and synthesisQuinazolinone synthesis and applications