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A highly D3R-selective and efficacious partial agonist (S)-ABS01-113 compared to its D3R-selective antagonist enantiomer (R)-ABS01-113 as potential treatments for opioid use disorder

Ewa Galaj, Guo‐Hua Bi, Benjamin Klein, Briana J. Hempel, Anver Basha Shaik, Emma Gogarnoiu, Jacob E. Friedman, Jenny Lam, Rana Rais, John F. Reed, Shelley H. Bloom, Tracy L. Swanson, Jennifer L. Schmachtenberg, Amy J. Eshleman, Aaron Janowsky, Zheng‐Xiong Xi, Amy Hauck Newman

2022Neuropsychopharmacology22 citationsDOIOpen Access PDF

Topics & Concepts

Partial agonistAgonistPharmacologyChemistryEnantiomerOpioidAntagonistOpioid receptorReceptorMedicineStereochemistryBiochemistryReceptor Mechanisms and SignalingNeurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology
A highly D3R-selective and efficacious partial agonist (S)-ABS01-113 compared to its D3R-selective antagonist enantiomer (R)-ABS01-113 as potential treatments for opioid use disorder | Litcius