A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex
Seung Wook Yang, Lei Li, Jon P. Connelly, Shaina N. Porter, Kiran Kodali, Haiyun Gan, Jung Mi Park, Klementina Fon Tacer, Heather Tillman, Junmin Peng, Shondra M. Pruett‐Miller, Wei Li, Patrick Ryan Potts
Topics & Concepts
BiologyUbiquitin ligasePolyadenylationUntranslated regionCarcinogenesisUbiquitinCancerMessenger RNACancer researchPTENGeneticsCell biologyMolecular biologyGeneSignal transductionPI3K/AKT/mTOR pathwayRNA Research and SplicingRNA modifications and cancerRNA and protein synthesis mechanisms