Hypoxia-induced epigenetic regulation of breast cancer progression and the tumour microenvironment
Alina L. Capatina, Jodie R. Malcolm, Jack Stenning, Rachael L. Moore, Katherine S. Bridge, William J. Brackenbury, Andrew N. Holding
Abstract
in mediating hypoxic adaptation via chromatin remodelling, transcription factor recruitment and changes in signalling pathways; and we briefly summarise some of the findings regarding vesicle secretion and paracrine induced epigenetic reprogramming upon hypoxic exposure in breast cancer. By summarising these observations, this article highlights the heterogeneity of breast cancers, presenting a series of pathways with potential for therapeutic applications.
Topics & Concepts
EpigeneticsHypoxia (environmental)Tumor microenvironmentBreast cancerCancer researchCancerBiologyMedicineDNA methylationInternal medicineChemistryGeneGeneticsGene expressionOxygenOrganic chemistryEpigenetics and DNA MethylationCancer, Hypoxia, and MetabolismRNA modifications and cancer