Litcius/Paper detail

Discovery of a chiral fluorinated azetidin-2-one as a tubulin polymerisation inhibitor with potent antitumour efficacy

Hairong Tang, Jiayi Cheng, Yuru Liang, Yang Wang

2020European Journal of Medicinal Chemistry26 citationsDOI

Topics & Concepts

CombretastatinChemistryTubulinAngiogenesisMicrotubuleIC50StereochemistryPharmacologyCell cultureCell growthCell cycleSmall moleculeApoptosisIn vitroBiochemistryCancer researchCell biologyGeneticsMedicineBiologySynthesis of β-Lactam CompoundsMicrobial Natural Products and BiosynthesisSynthetic Organic Chemistry Methods
Discovery of a chiral fluorinated azetidin-2-one as a tubulin polymerisation inhibitor with potent antitumour efficacy | Litcius