Translational Utility of Liquid Biopsies in Thyroid Cancer Management
Ayanthi Wijewardene, Marthe Chehade, Matti L. Gild, Roderick Clifton‐Bligh, Martyn Bullock
Abstract
Liquid biopsies are a novel technique to assess for either circulating tumor cells (CTC) or circulating tumor DNA (ctDNA and microRNA (miRNA)) in peripheral blood samples of cancer patients. The diagnostic role of liquid biopsy in oncology has expanded in recent years, particularly in lung, colorectal and breast cancer. In thyroid cancer, the role of liquid biopsy in either diagnosis or prognosis is beginning to translate from the lab to the clinic. In this review, we describe the evolution of liquid biopsies in detecting CTC, ctDNA and miRNA in thyroid cancer patients, together with its limitations and future directions in clinical practice.
Topics & Concepts
Liquid biopsyMedicineThyroid cancerBiopsyCirculating tumor cellThyroidColorectal cancerCancermicroRNABreast cancerPathologyOncologyPeripheral bloodLung cancerInternal medicineGeneBiologyMetastasisBiochemistryCancer Genomics and DiagnosticsGenetic factors in colorectal cancerCancer Cells and Metastasis