Milk and Dairy Products Intake Is Related to Cognitive Impairment at Baseline in Predimed Plus Trial
Araceli Muñoz‐Garach, Isabel Cornejo‐Pareja, Miguel Ángel Martínez‐González, Mònica Bulló, Dolores Corella, Olga Castañer, Dora Romaguera, Jesús Vioqué, Ángel M. Alonso‐Gómez, Julia Wärnberǵ, J. Alfredo Martínéz, Luís Serra‐Majem, Ramón Estruch, M. Rosa Bernal‐López, José Lapetra, Xavier Pintó, Josep A. Tur, José López‐Miranda, Aurora Bueno‐Cavanillas, Miguel Delgado‐Rodríguez, Pilar Matía‐Martín, Lidia Daimiel, Vicente Martín, Josép Vidal, Lucía Prieto, Emilio Ros, Fernando Fernández‐Aranda, Lucía Camacho‐Barcia, Carolina Ortega‐Azorín, María Soria, Miquel Fiol, Laura Compañ‐Gabucio, Leire Goicolea‐Güemez, Jessica Pérez‐López, Nuria Goñi, J. Pérez‐Cabrera, Emilio Sacanella, José Carlos Fernández‐García, L. Miró-Moriano, Mariano Gimenez‐Gracia, Cristina Razquín, Indira Paz‐Graniel, Patricia Guillem‐Sáiz, María Dolores Zomeño, Manuel Moñino, Alejandro Oncina-Cánovas, Itziar Salaverria‐Lete, Estefanía Toledo, Jordi Salas‐Salvadó, Helmut Schröder, Francisco J. Tinahones, Predimed‐Plus Investigators
Abstract
SCOPE: To examine the association between milk and dairy products intake and the prevalence of cognitive decline among Spanish individuals at high cardiovascular risk. METHODS AND RESULTS: Cross-sectional analyses are performed on baseline data from 6744 adults (aged 55-75 years old). Intake of milk and dairy products is estimated using a food frequency questionnaire grouped into quartiles. The risk of developing cognitive impairment is based on the Mini-Mental State Examination (MMSE). A higher prevalence of cognitive decline was found in subjects who consumed more grams. Patients with worse MMSE score (10-24) consumed a mean of 395.14 ± 12.21 g, while patients with better MMSE score (27-30) consumed a mean of 341.23 ± 2.73 g (p < 0.05). Those subjects with the lower milk consumption (<220 g/day) had a higher MMSE score (28.35 ± 0.045). Higher intake of fermented dairy products was observed in participants with a lower MMSE score (OR 1.340, p = 0.003). A positive correlation was found between the consumption of whole milk and the MMSE score (r = 0.066, p < 0.001). CONCLUSIONS: These findings suggest that greater consumption of milk and dairy products could be associated with greater cognitive decline according to MMSE. Conversely, consumption of whole-fat milk could be linked with less cognitive impairment in the cross-sectional study.